5AM Ventures is a seed-stage fund focused on creating and building biotech companies.

Achaogen is discovering and developing life-saving antibiotics.

Alexza is a specialty pharmaceutical company developing fast onset medications.

Biotie is a specialized drug development company focused on the development of drugs for neurodegenerative and psychiatric disorders and inflammatory diseases

FivePrime accelerates drug discovery by rapidly isolating and assaying the world’s largest collection of pharmaceutically relevant targets and therapeutics from the human genome.

Flap is a non operating company with rights to future milestones and royalties from GlaxoSmithKline related to the advancement of Amira’s FLAP inhibitor.

Flexion is developing novel therapeutics for the targeted treatment of musculoskeletal disorders.

Fluidigm has developed the biological and chemical equivalent of the integrated circuit called Integrated Fluidic Circuits (IFC’s). IFC’s incorporate tens of thousands of miniature channels, pumps and valves.

GenSight is a leading company in gene therapy specialized in prevention of loss of vision and restoration of sight.

Groove Biopharma develops therapeutics using Minor Groove Binder Technology (MGB) to affect cellular processes involving microRNAs.

Helicos BioSciences Corporation is developing instruments for high-speed sequencing of DNA or RNA without amplification.

Immune Design uses breakthrough technology to develop new vaccines for the prevention and treatment of infectious disease, based on a novel understanding of the role of dendritic cells in the immue system.

Inception 1 is translating biological insights into novel, first-in-class, small molecule drugs to treat diseases of aging.

Inception 2 is focused on Oncology. The company is translating biological insights into novel, first-in-class small molecule drugs for CLL and other oncology indications spanning both liquid and solid tumors.

Inception 3 is focused on the discovery of therapeutics for sensorineural hearing loss.  The company has entered into a partnership with Roche with a pre-negotiated acquisition at IND.

Metabolex discovers and develops novel therapeutics to treat Type 2 Diabetes and related metabolic disorders.

Novira Therapeutics is an antiviral drug discovery company that is focused on the discovery and development of first-in-class antiviral therapeutics for the treatment of chronic HBV infections.

Okairos is a clinical stage biopharmaceutical company using a best-in-class, proprietary genetic vaccine technology to develop vaccines for major unmet diseases, such as malaria, hepatitis C (HCV) and a universal influenza vaccine.

OpGen is developing a molecular biology system to automate rapid (2-hour) identification of infection-causing bacteria for deployment in the hospital microbiology lab.

Panmira focuses on clinical development of CRTH2 program for multiple allergic and inflammatory conditions.

Pathwork Diagnostics (fka Predicant Biosciences, Inc.) is developing innovative molecular diagnostic tests for cancer – initially for “tumor of unknown origin”.

PhaseRx is developing a novel approach to intracellular delivery of macromolecules.

Quanticel is a pharmaceutical company focused on the development of improved cancer therapeutics and their companion diagnostics.

RuiYi is a drug discovery and development company focused on first-in-class antibodies targeting G protein coupled receptors (GPCRs).

Semprae Laboratories a women’s sexual health and vitality company, providing products and content.

Spark Diagnostics is a diagnostics company utilizing next-gen sequencing technology to more efficiently and effectively diagnose disease.

Theraclone Sciences, Inc. is focused on developing novel human therapeutic antibodies for the treatment of infectious diseases.

Transcept Pharmaceuticals, Inc. is a specialty pharmaceutical company focused on the development and commercialization of proprietary products that address important therapeutic needs in the field of neuroscience.

Veracyte is a start-up company focused on molecular diagnostics.

VLST Corp. has developed a novel and streamlined approach to speed the development of effective therapeutics for the treatment of inflammatory and autoimmune diseases.